Fibromyalgia and Narcolepsy Drug Sodium Oxybate

Last Updated on September 23, 2022 by amin


What is the difference between Xyrem and Xywav?

Xywav is a low-sodium version of Xyrem, which carries warnings about its high sodium content. Both drugs contain the active ingredient oxybate, but the new offering has 92% less sodium, or about 1g to 1.5g per night, than Xyrem at the recommended dosage.

Does fibromyalgia cause you to sleep a lot?

Many people with fibromyalgia have another sleep disorder. For more than half of them, it’s restless legs syndrome (RLS). Having both conditions can make you sleepier during the day.

What is the difference between Vyvanse and methylphenidate?

Ritalin is a brand name for methylphenidate, and Vyvanse is the brand name for lisdexamfetamine. Both drugs are CNS stimulants and both are believed to have a similar mechanism of action; however, some trials indicate that Vyvanse may be more effective at relieving ADHD symptoms than Ritalin.

What is the best diet for someone with fibromyalgia?

Aim for a well-rounded diet

  • fresh fruits and vegetables.
  • whole grains.
  • healthy fats.
  • low fat dairy.
  • lean protein, such as chicken or fish.

Is fibromyalgia worse in winter?

During colder seasons, the symptoms of fibromyalgia can worsen. This may not be the case for everyone, as some are unbothered during winter while others experience more pain than usual. If you are one of those who experiences pain during colder weather, here are some tips to help alleviate symptoms. 1.

What are the side effects of sodium oxybate?

Sodium oxybate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • bedwetting.
  • headache.
  • dizziness.
  • feeling drunk.
  • shaking of a part of your body that you cannot control.
  • feelings of numbness, tingling, pricking, burning, or creeping on the skin.

What schedule is sodium oxybate?

GHB is a Schedule I controlled substance under the Controlled Substances Act. FDA-approved products containing sodium oxybate, including Xyrem and now the generic version of Xyrem, are controlled under Schedule III.

How many people have died from Xyrem?

As of June 30, the F.D.A. had recorded more than 27,000 serious adverse events for patients taking Xyrem or Xywav, including 753 deaths, according to the agency’s public database of such reports.

Does having narcolepsy make you immunocompromised?

A number of conditions are associated with elevated risk of significant complications of the infection, including individuals whose immune systems are suppressed through disease or medication. While narcolepsy is thought to have an immune basis, this does not constitute suppression of the immune system.

Does CBD oil help fibromyalgia?

CBD may help fibromyalgia, but research includes other cannabinoids, too. Most of the studies on managing fibromyalgia with cannabinoids have included THC, which is illegal in some states. These studies have found that people with fibromyalgia experience some improvements in pain when taking CBD combined with THC.

How do you get sodium oxybate?

Sodium oxybate is not available at retail pharmacies. Sodium oxybate is available only through a restricted distribution program called the Xywav and Xyrem REMS Program. It is a special program to dist

Is Concerta a stimulant?

Concerta and Adderall are medicines children and adults can take to manage their ADHD symptoms. They’re both stimulants — the most common type of drug used to treat the disorder.

Is bed rest good for fibromyalgia?

Not getting a proper night’s sleep will only aggravate your chronic pain and fatigue. Finding a solution to your sleep problems will not cure your fibromyalgia, but it will reduce your pain and fatigue. And since those are arguably the most debilitating fibromyalgia symptoms, that may be consolation enough.

Does Concerta help narcolepsy?

Concerta is a central nervous system stimulant. It is available by prescription and is often prescribed as part of a total treatment plan for ADHD. Concerta is also used to treat a sleep disorder called narcolepsy. The medication is categorized as a schedule II controlled substance because it can be habit-forming.

Does sugar worsen fibromyalgia?

Here are some food types to avoid: Sugar. Research shows that eating foods high in sugar can increase fibromyalgia pain because they put excess stress on the body, contributing to pain, obesity and inflammation.

What hormone is associated with narcolepsy?

Orexin Hormone Some research indicates that the loss of orexin-producing cells in the hypothalamus (a structure at the base of the brain) is a factor that is associated with narcolepsy. Orexin (also called hypocretin) is a hormone that, among other functions, has a role in wakefulness and increases appetite.

Can Adderall be used for narcolepsy?

Adderall can be very effective in treating ADHD or narcolepsy symptoms but for a significant number of patients, medications are not helpful. In fact, as many as 30% of children with ADHD do not respond to stimulants or cannot tolerate the side effects.

Which is better for narcolepsy Adderall or Ritalin?

Is Ritalin or Adderall better? Ritalin and Adderall are both effective prescription drugs to treat ADHD and narcolepsy. Research has shown that Ritalin may be better for children and adolescents while Adderall may be better for adults.

Is sodium oxybate addictive?

Sodium oxybate may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it.

What is the root cause of fibromyalgia?

Fibromyalgia is often triggered by a stressful event, including physical stress or emotional (psychological) stress. Possible triggers for the condition include: an injury. a viral infection.

Is narcolepsy an autoimmune disease?

There is increasing evidence that narcolepsy is an autoimmune disorder. Autoimmune disorders are caused when the body’s immune system mistakenly attacks healthy tissue or cells. In narcolepsy, the immune system destroys certain brain cells that produce a peptide called hypocretin.

How does Xyrem help with narcolepsy?

Xyrem is approved to treat narcolepsy (a sleep disorder that can make you feel extremely tired). It works by reducing cataplexy (sudden muscle weakness or paralysis) and excessive daytime sleepiness (EDS). Xyrem belongs to a class of drugs called central nervous system (CNS) depressants.

How much does sodium oxybate cost?

Cost. In the US, the cost (as of Q3 2015) of Xyrem is $5,468.09 per 180 mL bottle (500 mg/mL)(a 10 to 15-day supply) As of 2017 the cost of sodium oxybate in the UK was 540.00 to 1,080.00 for a thirty day supply, which at typical doses is 6,500 to 13,100 per year.

Is sodium oxybate a stimulant?

Sodium oxybate, the sodium salt of gamma-hydroxybutyrate (GHB), an endogenous metabolite of gamma-aminobutyric acid (GABA), is a central nervous system depressant.

How does sodium oxybate treat narcolepsy?

Several clinical studies have shown that sodium oxybate can reduce feelings of sleepiness as measured by the Epworth Sleepiness Scale. With sodium oxybate, people with narcolepsy generally stay awake longer during the Maintenance of Wakefulness Test, although they still fall asleep faster than normal.

What happens when you stop taking Xyrem?

If you suddenly stop taking Xyrem, you may experience withdrawal symptoms. You may find that cataplexy attacks return and, in rare cases, you may experience insomnia, headache, anxiety, dizziness, sleeping problems, sleepiness, hallucination and abnormal thinking.

Is Tramadol good for fibromyalgia?

Finally, tramadol is a weak mu-opioid receptor agonist and weak serotonin and norepinephrine antagonist that has resulted in relief of fibromyalgia pain. Tramadol can be paired with acetaminophen to reduce pain even further. TCAs were the mainstay of therapy for fibromyalgia for many years.

What is the best muscle relaxer for fibromyalgia?

Two muscle relaxants called Zanaflex and Flexeril are among the drugs used to treat fibromyalgia.

Are there any new breakthroughs on fibromyalgia?

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London, in collaboration with the University of Liverpool and the Karolinska Institute, has shown that many of the symptoms in fibromyalgia syndrome (FMS) are caused by antibodies that increase the activity of pain-

Is fibromyalgia worse at night?

Fibromyalgia is a condition that causes pain in muscles and soft tissues all over the body. It is an ongoing (chronic) condition. It can affect your neck, shoulders, back, chest, hips, buttocks, arms, and legs. The pain may be worse in the morning and evening.

What supplements should I take for narcolepsy?

Natural cures for narcolepsy include:

  • Guarana, which is a natural stimulant.
  • Cayenne pepper.
  • Ginkgo biloba, which increases blood flow to the brain.
  • Ephedra, which increases energy levels.
  • Gotu kola, which reduces fatigue.
  • Rosemary tea.
  • B complex vitamins, which are important in the sleep-wake cycle.

Is melatonin good for fibromyalgia?

Some preliminary findings show that melatonin may be effective in treating fibromyalgia pain. Most patients with fibromyalgia have sleep problems and fatigue, and it’s thought that melatonin may help relieve these symptoms. Melatonin is generally regarded as safe with few to no side effects.

Can narcolepsy go into remission?

For many people with narcolepsy, the disease remains generally stable over time. In some cases, certain symptoms may improve as the patient ages18, and rarely, remission of symptoms may happen spontaneously19.

Does Xyrem cause weight loss?

Official Answer. Xyrem (sodium oxybate) can cause weight loss, which is thought to be due to the medication enabling people to increase their physical activity and decrease their calorie intake.

How long does sodium oxybate stay in your system?

It is eliminated mainly by metabolism with a half-life of 0.5 to 1 hour.

Is sodium oxybate addictive?

Sodium oxybate may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it.

Do hot showers help fibromyalgia?

Heat, especially moist heat, may relieve soreness and stiffness from fibromyalgia by boosting blood flow to the places where you hurt. Apply a warm, moist washcloth to the painful area or try taking a shower or soaking in a bath. You also can reduce the deep muscle pain of fibromyalgia with a cold pack.

Who should not take XYREM?

It is not known if XYREM is safe and effective in children less than 7 years of age. Do not take XYREM if you or your child: takes other sleep medicines or sedatives (medicines that cause sleepiness) drinks alcohol.

Does CBD help narcolepsy?

Narcolepsy and CBD A recent study has found that using a small dose of CBD can induce wakefulness in people suffering from narcolepsy and somnolence. And since studies have shown a link between anxiety and CBD, taking CBD oil for narcolepsy will also help in managing anxiety that comes with the sleep disorder.

Does Xyrem make you irritable?

Additional adverse reactions that occurred in ?2% of patients in any treatment group for three controlled adult trials and were more frequent in any XYREM treatment group than with placebo were diarrhea, upper abdominal pain, dry mouth, pain, feeling drunk, peripheral edema, cataplexy, muscle spasms, extremity pain, …

Can you take Xyrem and Xanax?

Interactions between your drugs Using sodium oxybate together with ALPRAZolam is not recommended. Combining these medications can significantly increase the risk of serious side effects such as respiratory depression, low blood pressure, fainting, coma, and even death.

What is sodium oxybate prescribed for?

Sodium oxybate is used to reduce the number of cataplexy (weak or paralyzed muscles) attacks or excessive daytime sleepiness (EDS) in patients with narcolepsy. Narcolepsy is an uncontrollable desire for sleep or a sudden attack of deep sleep.

Can Xyrem cause brain damage?

Xyrem has a high potential for abuse because it can cause changes in the activity of the brain and can also cause changes in your breathing, even at regular dosages or if you are taking other interacting medicines.

Does gabapentin help fibromyalgia?

New research supported by the National Institutes of Health’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) shows that the anticonvulsant medication gabapentin, which is used for certain types of seizures, can be an effective treatment for the pain and other symptoms associated with the

What is the latest treatment for fibromyalgia?

What is the new medication for fibromyalgia? The newest medication approved by the FDA to treat fibromyalgia is called Savella. It’s a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI) that helps the body respond to pain signals better.

Does fibromyalgia worsen with age?

Fibromyalgia is a chronic disease that is often a lifelong condition. But fibromyalgia is not a progressive disease, meaning it will not get worse over time. It also does not cause damage to your joints, muscles, or organs. Taking steps to treat fibromyalgia can help relieve your symptoms.

Why does fibromyalgia affect sleep?

Some polysomnographic data suggests people with the condition experience wakefulness during the non-rapid eye movement (NREM) stages of the sleep cycle and receive less slow-wave sleep as a result. Sleep and fibromyalgia share a bidirectional relationship.

How do you wake up with fibromyalgia?

Take a Warm Shower or Bath One of the quickest and easiest things you can do to lessen morning pain, stiffness, and other symptoms of fibromyalgia is harness the healing power of water. Warm showers or baths at bedtime and in the morning will help to relax muscles, and offer a fair amount of relief, says Nicholas P.

Why do fibromyalgia patients gain weight?

Fibromyalgia is a generalized pain condition. However, due to the pain associated with this condition along with fatigue, patients may find exercise and daily physical activity more difficult. Lack of exercise can naturally result in weight gain.

Who should not take Xyrem?

It is not known if XYREM is safe and effective in children less than 7 years of age. Do not take XYREM if you or your child: takes other sleep medicines or sedatives (medicines that cause sleepiness) drinks alcohol.

What is the strongest medication for narcolepsy?

Doctors often try modafinil (Provigil) or armodafinil (Nuvigil) first for narcolepsy. Modafinil and armodafinil aren’t as addictive as older stimulants and don’t produce the highs and lows often associated with older stimulants.

What are the long term effects of Xyrem?

Respiratory Depression and Sleep-Disordered Breathing XYREM may impair respiratory drive, especially in patients with compromised respiratory function. In overdoses, life-threatening respiratory depression has been reported.

What are the 8 symptoms of fibromyalgia?


  • Pain and Tenderness. The most common and well-known symptom of fibromyalgia is the all-over aches and pains many people experience. …
  • Fatigue. …
  • Sleep Issues. …
  • Mood Disorders. …
  • Morning Stiffness. …
  • Swelling or Tingling in Your Extremities. …
  • Headaches. …
  • Irritable Bowel Syndrome.

Can Xyrem be prescribed for idiopathic hypersomnia?

Both Xywav and Xyrem contain the same boxed warnings about CNS depression and dependency and misuse risks. They also tend to cause many of the same side effects, including nausea, headache, and dizziness. But unlike Xywav, Xyrem isn’t FDA-approved to treat idiopathic hypersomnia.

What happens if I take too much sodium oxybate?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of sodium oxybate can be fatal. Overdose symptoms may include sweating, vomiting, severe confusion, loss of balance or coordination, or seizure (convulsions).

Is Nuvigil stronger than Provigil?

Provigil and Nuvigil may help people who suffer sleepiness from shift work disorder stay more alert. Still, experts warn that there are no long-term studies on the effects of these drugs on a healthy brain.

Provigil vs Nuvigil.

Brand Name Provigil Nuvigil
Strengths 100 mg and 200 mg 50 mg, 150 mg, 200 mg, 250 mg

What is the best antidepressant for fibromyalgia?

Duloxetine (Cymbalta), an antidepressant, is another drug approved by the FDA for the treatment of fibromyalgia. Cymbalta is an antidepressant that belongs to a class of drugs called serotonin and norepinephrine reuptake inhibitors (SNRIs).

Fibromyalgia and Narcolepsy Drug Sodium Oxybate

Sodium oxybate is the active ingredient in the narcolepsy drug Xyrem, which has been studied for fibromyalgia (FMS) and is sometimes used off-label for FMS and chronic fatigue syndrome (ME/CFS). This drug carries a risk of addiction and abuse, so it’s classified as a Schedule III controlled substance.Oct 17, 2020

Is Xyrem approved for fibromyalgia?

Aug. 20, 2010 — An FDA advisory panel today overwhelmingly rejected the application of Jazz Pharmaceuticals for the approval sodium oxybate (Xyrem) for the treatment of fibromyalgia. The drug is chemically similar to GHB, widely considered a date-rape drug.

What does fibromyalgia feel like in legs?

Many people describe it as a deep, dull ache within the muscles that gets worse with strenuous exercise. The pain can also be throbbing, shooting, or burning. And it may radiate from areas of the body known as tender points, and can be accompanied by numbness or tingling in the limbs.

Is Vyvanse approved for narcolepsy?

Vyvanse is used off-label to treat narcolepsy. It is approve for use to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe binge eating disorder.

Why do narcoleptics gain weight?

People with narcolepsy have been found to be prone to weight gain even when they don’t eat more. Low metabolism may be part of the reason. When you have narcolepsy, your body burns calories more slowly. Some researchers have suggested that daytime sleepiness makes people less active, and so more likely to gain weight.

What are the long term effects of Xyrem?

Respiratory Depression and Sleep-Disordered Breathing XYREM may impair respiratory drive, especially in patients with compromised respiratory function. In overdoses, life-threatening respiratory depression has been reported.

Is Xyrem approved for fibromyalgia?

Aug. 20, 2010 — An FDA advisory panel today overwhelmingly rejected the application of Jazz Pharmaceuticals for the approval sodium oxybate (Xyrem) for the treatment of fibromyalgia. The drug is chemically similar to GHB, widely considered a date-rape drug.

What is the drug of choice for fibromyalgia?

Duloxetine (Cymbalta) and milnacipran (Savella) may help ease the pain and fatigue associated with fibromyalgia. Your doctor may prescribe amitriptyline or the muscle relaxant cyclobenzaprine to help promote sleep.

What should you avoid if you have fibromyalgia?

Other foods and ingredients that may cause symptoms for some people include, but are not limited to:

  • Gluten.
  • Red meat.
  • Fruits and vegetables in the nightshade family, such as tomatoes, white potatoes, green peppers, and goji berries.
  • Dairy products.
  • Eggs.
  • Caffeine.

Do you need more sleep with fibromyalgia?

In those suffering with fibromyalgia, some have other conditions that also result in poor sleep quality. By addressing these other problems, people may experience more restful sleep, leading to improved daily functioning.