Klinefelter Syndrome Signs and Symptoms

How common is Klinefelters?

Klinefelter syndrome affects about 1 in 650 newborn boys. It is among the most common sex chromosome disorders, which are conditions caused by changes in the number of sex chromosomes (the X chromosome and the Y chromosome).

Is Klinefelter’s intersex?

Therefore, according to the NZKA, not all XXY individuals will develop Klinefelter Syndrome, for the Syndrome is simply a form of male hypogonadism, caused by a lack of testosterone: thus XXY is not an intersex condition.

Does Klinefelter cause infertility?

Klinefelter syndrome is common in infertile men with oligospermia or azoospermia (5 to 10 percent). Infertility in men with Klinefelter syndrome is caused by a precipitous drop in sperm count.

Who is most likely to get Klinefelter syndrome?

Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

Is Klinefelter syndrome a disability?

If you or your dependent(s) are diagnosed with Klinefelter Syndrome and experience any of these symptoms, you may be eligible for disability benefits from the U.S. Social Security Administration.

Can Klinefelter have facial hair?

Physical differences in males with Klinefelter syndrome often are evident after the onset of puberty. However, the characteristic phenotypic findings (e.g., lack of gonadal development; sparse or absent facial hair; and thin, long-limbed body habitus) usually are subtle.

How do I know if I am intersex?

So what does intersex look like?

  1. a clitoris that’s larger than expected.
  2. a penis that’s smaller than expected.
  3. no vaginal opening.
  4. a penis without a urethra opening at the tip (the opening might instead be on the underside)
  5. labia that are closed or otherwise resemble a scrotum.
  6. a scrotum that is empty and resembles labia.

Can Klinefelter syndrome be cured?

There’s no cure for Klinefelter syndrome, but some of the problems associated with the condition can be treated if necessary. Possible treatments include: testosterone replacement therapy. speech and language therapy during childhood to help with speech development.

Can people with Klinefelter be Short?

About 25% of patients have fifth-finger clinodactyly. Some males with Klinefelter syndrome variant 49,XXXXY have short stature.

What is the death rate of Klinefelter syndrome?

We found that Klinefelter syndrome was associated with a significant increase in mortality risk of 40% (hazard ratio, 1.40; 95% confidence interval, 1.13-1.74), corresponding to a significantly reduced median survival of 2.1 yr.

CAN XXY have babies?

It is possible that an XXY male could get a woman pregnant naturally. Although sperm are found in more than 50% of men with KS3, low sperm production could make conception very difficult.

What is the other name for Patau syndrome?

Patau’s syndrome is a serious rare genetic disorder caused by having an additional copy of chromosome 13 in some or all of the body’s cells. It’s also called trisomy 13.

Klinefelter Syndrome Signs and Symptoms

Does Klinefelter syndrome cause gender dysphoria?

Introduction: An increased risk of autistic traits in Klinefelter syndrome (KS) has been reported. In addition, some studies have shown an increased incidence of gender dysphoria (GD) and paraphilia in autism spectrum disorder.

How many men have Klinefelters?

Approximately 1 in 500-600 males is born with an extra X chromosome. The prevalence rate is 5-20 times higher in males who are mentally challenged than in the general male population. Approximately 250,000 men in the United States have Klinefelter syndrome.

Is Klinefelter syndrome fatal?

In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

How do you diagnose Klinefelter syndrome?

Blood or urine samples can reveal abnormal hormone levels that are a sign of Klinefelter syndrome. Chromosome analysis. Also called karyotype analysis, this test is used to confirm a diagnosis of Klinefelter syndrome. A blood sample is sent to the lab to check the shape and number of chromosomes.

What race is affected by Klinefelter syndrome?

Klinefelter syndrome does not have any racial predilection.

Why are Klinefelter males tall?

From early school age, boys with Klinefelter’s syndrome tend to be taller (increased leg length) because testosterone normally stops boys growing after puberty. This increase in height is maintained throughout life. Patients with Klinefelter’s syndrome may have reduced coordination compared with other boys.

How does Klinefelter syndrome affect a person’s life?

Klinefelter syndrome puts males at greater risk of breast cancer, some other cancers, and some other diseases like type 2 diabetes, varicose veins and problems with blood vessels, problems with sexual function, and osteoporosis (weak bones) later in life.

How long is the average lifespan of a person with Klinefelter syndrome?

What Is the Life Expectancy for Klinefelter Syndrome? Life expectancy for patients with Klinefelter syndrome is reduced by five to six years. Patients diagnosed at a younger age seem to have a shorter lifespan, possibly because diagnosis at an earlier age is associated with a more severe phenotype.

What age is Klinefelter syndrome diagnosed?

Klinefelter syndrome usually is not diagnosed until the time of puberty. At this point, the boy’s testicles fail to grow, and you may start to notice other symptoms.

Can you be short with Klinefelter syndrome?

Although one of the most characteristic features of Klinefelter syndrome is tall stature, some uncommon variants are associated with short stature (49 XXXXY, isochromosome Xq) [35]. To the knowledge, there are few reported cases of Klinefelter syndrome and short stature secondary to growth hormone deficiency [1, 4].